I was on Depo for 3 months while breastfeeding my son. It was my only option - can't be on the pill while bfing and I'm allergic to latex, so ... not an option. I did NOT react well to the Depo at all. I did have a little bleeding, but the headaches at the beginning and coming off of it were horrendous. I also gained weight (avg wt gain is 5 lbs in the first year, from what I've read) and it made me feel ... just off. It's difficult to explain, but I did not feel like myself. And - I don't think it was hormonal changes from having the baby (as this was my second child) and as soon as it was out of my system - I was back to normal.

I have a friend that was on it for 5 years and stopped taking it over a year ago. She's having a tough time conceiving a baby, had one miscarriage, and had withdrawal like symptoms for the first 2-3 weeks after stopping the injections.

Some people don't react to it at all (like Nanci). I guess it's an individual physiology thing.