Quote Originally Posted by WindingRoad View Post
First don't ever feel odd about asking your doctor questions. Any good clinician will be receptive and should not take these questions personally. No one knows you better than you so they need to know what you are thinking in terms of treatment too. It's treating the whole person not just their body.

Am I understanding that the blocking treatment means that your TSH is somehow ineffective at producing T3 and T4? Or something is possibly aberrant about the T3 and T4 making them ineffective?
The blocking part of block and replace is the use of anti-thyroid meds to block the production of thyroid hormone. The drugs also help lower the antibodies that cause GD in the first place. In an effort to keep thyroid levels stable, some docs then add in a hormone replacement drug. In my case, such a drug would be used to keep me from going into a hypo state. Block and replace can also help patients from developing a resistance to the anti-thyroid meds. In the end, the approach often leads to more stability and, ultimately, to remission.

The standard wisdom that I've seen is that you use just enough anti-thyroid meds to keep Free T4 at or slightly above the mid-range. In my case, we're having a hard time finding a small enough dose to do that, which my necessitate the use of block and replace. This, of course, is my amateur opinion.

I do agree with you that a good clinician should be willing to answer my questions. My concern with my current doc is that she doesn't know the answers to my questions. Based on comments my doc has made in the past, it would appear that she's focused exclusively on my TSH levels. Once a patient is on meds, TSH is not a reliable number to look at. For a lot of GD patients, their TSH levels remain extremely low even after drug therapy. My understanding is that so long as their Free T4 and T3 levels are good, the therapy is working and they should feel relatively good. My original concern about my doc is that she doesn't seem to be looking at the appropriate lab values. How can she get me where I need to be if she doesn't even know what to look at? Ugh.