For me, personally, I try and look for a "seamless" chamois. And I tend to go with the "less is more" idea. I've found that the thinner, denser chamois pads are far more comfortable on longer rides than the puffy, bulky, diaper-like ones. I also look for pads that are narrower through the crotch/inner thigh area, as I have found that wider ones tend to chafe me in that area.