Ok, decided to update my trial and error results. I originally was on the Lady Selle Italia Gel, did some good miles on it, but after a while, it became so uncomfortable. Got a lot of suggestions on this thread, which were so helpful and appreciated!! Since I last wrote in, I tried moving my Selle Italia nose up a bit and then down a bit, but it wasn't really great. Then tried a Specialized Jett, felt good initially then uh oh. Next tried a saddle without a cutout, a Selle Royal Lookin, but couldn't even make two miles on it. Lastly, I got a Cobb V Flow Plus to try. Went onto their website and followed the setup directions. Found that according to them, my saddle was actually too far back, and I moved it forward about two inches, maybe more. Went out today and had such an amazing, comfortable ride for the first 13 or so miles….then it hit. Ouch!! That is such a hard saddle, but much better on the girly bits which is where I was having the initial trouble. With the Cobb, everything around them got sore this time!! I can't seem to get it right. What I will try now is to put the Selle Italia back on and move it forward two or so inches and see what happens. What the Cobb website said is if you measure from tip of your index finger to back of your elbow, that's the distance the tip of the nose of your saddle should be from the middle of the handlebars, just for those newbies like myself. Mine was much farther back. Anyway, sorry for the long post!!