I have a Thudbuster on my hardtail mountain bike. Are you looking to soften up your 29er for trail riding by using the Thudbuster? I'm otherwise not sure why you'd want to use it to ride on the road. Because it effectively changes your saddle placement (your saddle goes compresses down and back), it may make your pedal stroke less efficient. You'll just end up having to work harder. I guess I'm just trying to figure out what you're trying to accomplish. If you want to make your 29er more of a road bike, put some slicks (tires) on it or get a dedicated set of wheels with slicks for the bike so that you can go from road to trail/gravel more easily. And if you want to have a snow bike, put some snow tires on the 29er.
Live with intention. Walk to the edge. Listen hard. Practice wellness. Play with abandon. Laugh. Choose with no regret. Continue to learn. Appreciate your friends. Do what you love. Live as if this is all there is.
--Mary Anne Radmacher