Another thing to consider is the possibility that your positioning on the bike might be too aggressive. I think this is likely the key to my own persistent crotch issues...we've raised my seat, lowered my seat, moved it forward, backwards, tilted up, down...tried various shorts and saddles. I'm still ending up pinched and raw. Some shorts and saddle combos aren't bad, but I'm still ending up beat up after most rides...even with globs of chamois lubes.

So last night I had my hubby flip my stem back to a somewhat less aggressive posture. The rest of my body does fine relatively horizontal, but my hooha is the deal-breaker.

The weird thing is that I'm generally OK in the drops, it's on the hoods when I end up too much on a delicate and sensitive "sweet spot." I prefer riding on the hoods for the bulk of my miles, so that doesn't work.