I was sort of in the same boat as you, CyborgQueen. Got sized up at a Trek dealer and was told 54cm 2100 WSD (paid $1400) would be perfect fit for me (I am 5'6", short torso, longer legs). Felt a bit stretched out on the bike from day 1. The guy there never really did a complete fit, hence the reason I could never really get comfortable. I found another shop that did offer "pro" fits for a hefty price tag of $200. Reluctantly, I brought my Trek in for a pro fit and was told that the frame was too large and there wasn't much he could do. He said he could tweak it only so much. So I ended up buying a 51cm Cervelo ($3200) from that shop. The bike was awesome, but it was way too aggressive of a geometry for my bad back. I rode it for a year and sold it. Now I have a 51cm Cannondale Synapse Carbon Fem 3 ($3000), but I continue to have fit issues with this bike too (primarily hand issues). I absolutely HATE the Ultegra components on it (I know this goes against most people's opinions of Ultegra) because the front shifting is SO incredibly stiff...similar to what you were saying about your left shifter and your wrist having to move so far to shift it. It has an extremely long throw. I am lusting for electronic shifting (either the DA Di2 or the new Ultegra Di2 coming out in Sept.). As you can see, this has been a rather expensive experiment in trying to find the right bike. Anyway...didn't mean to hijack your thread...just wanted to chime in to say that you are not alone and I truly hope that you (and I) eventually get THE perfect fitting bike. 
Linda
Last edited by nscrbug; 08-30-2011 at 07:30 PM.
2012 Seven Axiom SL - Specialized Ruby SL 155