Don't know much about wheelsets, as I'm riding my stock wheels and don't foresee switching them at the moment.

But in regards to tires, I can highly recommend Vittoria Diamante Pro (rode these for close to 4k miles with only 1 flat)...and right now I'm currently riding on Michelin Krylion tires, which have also been great. For me, I look for a tire that has decent grip on both dry and wet pavement because I frequently get caught out in the rain.