Wow, Darcy, it sounds like you hit the nail on the head! Even at night if it gets hot in the house and I get the slightest bit of skin warmth or moisture in that same area it starts itching. FWIW I am absolutely totally OCD about getting my shorts off and into the shower immediately after every ride. I simply can't stand to wear the shorts after the biking activity has stopped. Then I wash them immediately after my shower in Penguin Sports Wash, which seems to work well. Thanks for the tips, laldies! I was pointing a finger at my chamois cream but I think it's something different than chafing.