If I raise the seat up high enough to get full leg extension and no knee pain, the saddle (ANY saddle!) is doing one of these 3 things depending on how it's adjusted:
A)chafing away at the front of me
B)jammed up into the tops of my thighs
C) nose down in front, but pushing into sit-bones causing my piriformis muscle to cramp and sciatic pain.
If I lower the saddle enough so it doesn't offend anything "up there", my right knee hurts - and I ride flat pedals, so it can't be foot position related.
The paragraph above raises a number of concerns. I think a good bike fitter would save you a lot of time and pain.
Full leg ext....likely too high.
You need to know EXACTLY your foot position as it comes thru the point of max extension (parallel with seat tube) then adjust saddle height to get 150 deg knee bend. Which is lower than most think. Consider that any fore-aft adjustment of the saddle from here will affect this measurement.
I ride flat pedals, so it can't be foot position related Yes it can. depending on the set up and the shoes you use....there are a myriad of foot control/saddle height/knee stability issues that can come into play.



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