Along those same lines, there is also the newer Bontrager Affinity RL WSD or Affinity RXL WSD. I have a friend with a new Project One Madone, and the Affinity was the stock saddle on that bike and I haven't heard one complaint about it yet.
+1 on this!! also +1 on the no cut outs to prevent pressure points... as far as the Affinity saddles go I havent put many miles on these saddles but when I rode them on both the road and the mtn bike I loved them, as far as different sized women go if you go to your LBS they'll measure your sit bones (not your butt!) and the Bontrager saddles come in different withs to accomidate different sized sit bones.

kudos on sticking with the bike!! I had an aweful reaction to something "down there" a few days ago and was pretty miserable on my bike, I'm sure it's no comparison but it definetly wasn't fun