I can change my rear tire, but it does cause anxiety. For some reason, it is hard to picture how the wheel goes back on. Once I reach for the chain, it all becomes clearer.

I became more comfortable by putting new tires on in the comfort of the living room, with the Team Estrogen handout. (I also carry it in my handlebar bag). Do it over and over with no pressure. It helps.

Of course, simply carrying the right equipment with you goes a long way. I've frequently stopped to help people who didn't have a spare tube (and a different size from mine).