This thread has been very eye-opening and scary for me. I regularly take an Aleve before my weekend ride as I have chronic pain from my pelvic fracture in a 2005 cycling accident. I assume it's my SI joint and/or nerves around that area as my right lower back and buttock usually start aching at some point during a ride, and my right leg even feels a bit weird as if there is some nerve involvement. Getting off the bike and stretching helps for awhile, but then the pain recurs.

I have no idea if the Aleve helps at all, but I figured it might help a bit. Actually, I don't think it does make that much difference since when I forget to take it, I am just as likely to have a less painful ride than when I take it!

After reading all this, I'm just going to cut it out. Just not worth it.