Quick n' dirty version of research that I thought you all might appreciate:

Apparently there are people who do endurance events who live on Advil and other NSAIDs to get them through. The problem with it is a big long scientific explanation but I won't bore you with all of the details. Basically it boils down to if you NEED to take NSAIDS make sure you stay hydrated because they affect biological pathways to shut off pain but they also affect pathways that control the normal blood volume via your kidneys. Without these chemical messengers our bodies don't understand we need to hold on to our fluids and the body eliminates them when actually we need the water. This is why its so scary when people pop Advil while doing endurance events because you are likely already dehydrated. The damage to the kidneys starts because of fluid electrolyte imbalances in a critical point of the urine formation system. We absolutely must have a certain amount of sodium in very specific locations on the route of that urine formation system. Without the sodium, the body just doesn't hold on to the water when it should. This is the same concept as when you eat a bunch of salty food and get water gain. Destroying that electrolyte balance in the kidney can ultimately cause kidney failure if it goes on long enough.

Why women?

Apparently we use a LOT more painkillers than men. We are MUCH more likely to suffer from headaches, backaches and various forms of chronic pain. The female chronic pain sufferers who use high doses of NSAIDs regularly are the most at risk group. There is another complicating issue in that women, as we age tend to get dehydrated easier anyways. We also all know what we lose in the monthly cycle, this reduces the blood volume we have to work with too.

Moral of story:

Don't overdo it on your Ibuprofen, Acetaminophen and Aspirin. If you do have to take them stick to the recommended dosage and drink lots of water while taking them.