I know this much...a doctor buddy of mine makes a point of telling anyone who will listen to NEVER EVER take NSAIDS 6 hours before or after any endurance activity. Apparently the risk of renal failure is just too great under these circumstances. I have listened. A post-workout ice bath is safe and more effective, anyhow, IME. And pain is there for a reason. Sometimes masking it is courting worse pain in the end.

During a marathon I ran there were a couple of guys right behind me for the first 20+ miles who were popping Advil every hour. Made me cringe. Also made me wonder why they were running a marathon if they weren't ready or willing to endure some pain.