From the FDA's Q and A on the herpes zoster vaccine.
The effectiveness of Zostavax in preventing repeated episodes of shingles has not been demonstrated in clinical studies.
Which sometimes just means it is an endpoint that wasn't looked at. But the Q and A also comments that having an outbreak of shingles boosts immunity to the virus and that most people who have an outbreak of shingles usually don't have another. So I'm thinking that maybe they didn't look at that as an endpoint under the assumption that people with multiple outbreaks don't seem to benefit (or have) the immunity boost from the outbreak that most people have, so they maybe won't have that from the vaccine either? Just wildly speculating there.![]()




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