I personally can't ride any saddle without a cut-out. I had bad chafing and rawness in the most delicate areas without this and grew to dread riding. I ride the Terry Butterfly saddle now, and the only problem I have is occasional chafing (and a rare saddle sore) on the crease between the my inner thigh and crotch area. Those I can deal with!

The sit-bones do have to get used to a new saddle (or starting to cycle in general), but that tissue will toughen right up after a few rides if the saddle is okay for you otherwise.

Emily