Neosporin is great for saddle sores- which I never got until recently when I changed shorts. (gained weight during my long layoff). Chamois Butt'r really helps prevent them for me, and the clean shorts thing is absolutly true. I can't wait to get back into the other shorts, though, I think they made a big difference.
I've heard that a seat change, or seat position change, can make a big difference too, either makes 'em worse or clears 'em up. Something to think about.

Lizzy