I'm in MI too and I agree with Zoom-Zoom. Two layers is usually good. I usually only wear one layer on the bottom unless it's really bitter cold (teens with a 0 degree wind-chill).
I think the important thing is a good pair of running gloves and a good hat.
I also have issues with my chest being really sensitive to the cold. So I stock up on toe-warmers. They fit nicely into a sports bra and keep me very comfortable during the bitter cold runs.



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