while you still should check the beds in hotels, a catalog store called gaia used to carry a silk travel bag/ sleeping bag style sheet that kept you off of the questionably cleaned sheets in a hotel. I have one and use it whenever I do a cross country tour because between dealing with a) finding a motel that can house 20-30 women for one night, all preferably in ground floor, non smoking rooms, that is not in a huge suburb, and b) finding the next one withing a doable days ride for 6-8 weeks is a challenge which means that at times, the nights' lodging ends up being in less than totally desireable locales.

I also leave anything new or returning luggage outside in the garage and then go straight to the washer or a white garbage bag for 48 hours.

just saying....