I've been treating one with various products for over a month now.

What hasn't worked for me: acne cream, tea tree oil, A&D ointment

What HAS helped: cleaning with alcohol wipes IMMEDIATELY after the ride and putting on clean shorts/pants. Applying Bag Balm.

I tried popping mine, but only blood came out. One day later and it still looks the same (like a medium-sized pimple). So. Frustrating.