I can't take more than one ibuprofen in a day, or else I go into a swirling downhill spiral of GI symptoms, including pain in the upper GI area. I always take it with a Zantac, which helps, but still. There's been a few times when I've had sports related injuries that i wished I could take more, but I knew better.
After I had my first son, I had a lot of issues with my period (well, worse than usual, since i had issues right from age 11). At the time, in 1982, IB was a new thing. My doc gave me a prescription for it and that just about did me in.
2015 Trek Silque SSL
Specialized Oura
2011 Guru Praemio
Specialized Oura
2017 Specialized Ariel Sport