So, first run in the Synergy yesterday. 
Likes:
* It rides as light and as comfortably as I'm used to from the Intensity. It's hard to believe there's three liters of water on my back. Fit is rock-solid - I could often hear the water sloshing, but somehow I couldn't feel the weight of the water moving at all.
* I didn't think I'd have any use for the dual-chamber system, but my very first time out showed me what it's good for. On a steamy 88° day, I could load up the main water compartment with ice, mix Endurolytes extra strong in the other side, and not have the dilution change as the ice melted.
* As Yellow said, elastic clips hold the top of the bladder, so it doesn't slide down as it empties; elastic means it doesn't pull on the top of the pocket.
* The front zip pocket is big enough for my new phone (HTC Incredible)! Yay.
It will go into the corresponding pocket on the Intensity pack, but just barely - I have to open the zipper completely and wrestle with it a little, and I'm always afraid I'm going to rip the plastic bag that protects my phone, electronic car key and ID.
* The side mesh pockets are nicely placed and do seem secure. I surely wasn't stowing hat or gloves yesterday, but the pockets would work perfectly for that.
Dislikes:
* #1 is a big one. The final drink tube is too short. What's up with that? If I left the mixing valve clipped to the shoulder strap, I'd have to bend my neck and lift the strap with one hand, and the tube would still kink half the time. If I unclipped the mixing valve, it was a real PITA to clip back in, and it seems that too-frequent clipping/unclipping would create a lot of wear on the strap to where it eventually wouldn't stay put at all.
Luckily, for me this one is easily remedied. When the bladder fell apart on my Intensity pack last winter, I cannibalized it for parts, including the drink tube, so I have a replacement right here that's plenty long enough. But for someone who doesn't happen to have a spare lying around, it could be a problem. Nathan uses a larger diameter drink tube than Camelbak and Platypus (8 mm ID), and they don't sell replacements on their site. Does anyone know if this is the same size that Osprey uses? REI has replacement Osprey drink tubes.
* The bladder is pretty much impossible to dry. The filler cap is even smaller than the one on the bladder that came with my Intensity, and that was already a problem. Camelbak drying jigs won't even begin to fit inside. The only thing that will go in is a narrow wooden spoon (maybe 1-1/4" across at the widest) or my smallest silicone scraper, and neither one of those will stay turned sideways to spread the bladder enough to let the corners dry. The roll-top electrolyte chamber ought to be easier to dry, except there's an anti-reversion baffle that sufers from the same problem.
I washed it as soon as I got it, hung it upside down and propped open as best I could, and the corners were still wet when I took it down to use it five days later.
* I don't much care for the bite valve. I can live with it, but if it were up to me, I'd choose something different. And because of the larger tube diameter, Camelbak bite valves don't fit.
General fit note: It's a little bigger around than the Intensity. It fits me very nicely with the straps cinched all the way tight, and I'm small but not tiny. Very thin and/or small-boned women probably would not be able to wear this pack.
Speed comes from what you put behind you. - Judi Ketteler