I clean my chain (like everything else...) when I look at it and can go "Eew." Then I clean that with one of those handy chain machine things and degreaser. Then the cassette with a bit of degreaser on a rag, then the chainrings as much as I can without taking the whole thing apart. While the rear wheel's off I clean its rim and the rear brakes (consists mostly of removing the gunk. Stick wheel back on, then re-lube the chain. Then I clean the frame with a bit of lemon pledge on a rag.

I try to remember to wipe down my tires after every ride as my bike lives in my apartment, but that doesn't always happen.