I have both the Brooks 'S' type saddles and regular Brooks. I found that the 'S' saddles hammock area isn't as noticeable when I first ride it and the nose is pointed up a tiny bit. On the men's saddles--oooh boy. I have to drop the nose ever so slightly to reduce the pressure until the hammock area has softened up a little.

The women's saddles don't give you as much fore/aft wiggle room but it will support your sit bones and you're not as likely to ride more towards the nose. In terms of comfort, if I am sitting more upright the ladies saddle is comfie but I do run the risk of the saddle rubbing the area between my thigh and butt. It's that reason I swapped the Team Pro S to the Team Pro on the road bike. And as Knott pointed out, you don't have as much steering with a shorter nosed saddle.