For asthma, and since humidity is one of my triggers, I use my rescue inhaler 15 min before I ride. It's one of the things I carry with me when I ride. If air pollution is a trigger check to see when the pollution counts are the highest in your area. Not sure about Indy but the Cincy/Dayton area ranks pretty high for bad air.

When you finish your ride get out of your damp shorts ASAP. I often changed in the car.

Take it slow and as others have said you will get used to the humidity.