I really like the Novara bike commuter backpack from REI. There's a chest strap as well as a waist strap to hold it firmly in place. It has three different zippered compartments plus a handy place to stuff your bike lock. You can really pack it, almost too full to carry.It's bright yellow and has lots of reflective bits, a place to clip a blinkie light and good padding against your back. I use it when I ride my road bike to work.
When I ride my trusty Surly I use panniers. I really like them too. I use my Ortlieb front panniers on my back rack. They are the perfect size for day to day commuting, plus waterPROOF. That's important for my foul weather commutes. I don't feel like stuff gets too jostled in the panniers. They are usually stuffed fairly tight with "stuff". I don't seem to be able to travel light.Panniers are a good choice if you have any back issues. Plus, being the moist old bird that I am, my rain gear vents sooo much better with out the backpack.
bikerHen



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It's bright yellow and has lots of reflective bits, a place to clip a blinkie light and good padding against your back. I use it when I ride my road bike to work.
Panniers are a good choice if you have any back issues. Plus, being the moist old bird that I am, my rain gear vents sooo much better with out the backpack.
bikerHen

DH has a Chrome Metropolis (large classic messenger shape), and that cross strap fits right at his armpit, so I would probably avoid that one, but I would die without my Timbuk2. The volume on messengers is expandable, versus the static dimensions of a traditional backpack or panniers, and it shapes to fit your body so you can always shift things around to find a comfortable spot. 
