Yep, I love my saddle with a cut-out. I have a Selle-Italia Lady Gel Flow...so far, so good. It's not great on a trainer, but everyone tells me that no saddle is comfy on the trainer. The saddle that came with my bike was a bad fit everywhere--too narrow through the sit bones.
Definitely no to the undies with shorts. I have learned to go commando while running, too...either tights with no panties or a running skirt that has an attached brief with reversed seams.
I use chamois butter for anything over an hour, though I'm sure once I get outside that I won't use it for anything under 2.



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