I have a Shimano compact crank, and a 10 speed IRD 11-32 cassete, and it works perfectly. I happened to already have an Ultegra triple front derailleur, and that gave enough room that I didn't need a long cage rear derailleur. I remember when my lbs guy decided to try it out (without changing the rear derailleur), no one was sure it would work. That was over 2 years ago, and it's still working perfectly. No chain drop issues.