I've have Topolino's on my Litespeed that are better than I ever expected. I kept reading reviews of Ksyriums that said they were pretty harsh riding, and these were comments from men who I assume weigh more than I do, so I ruled them out. I wanted light weight wheels with low profile rims since I don't race but do ride long distances. The Topolinos have a smooth as silk ride and soak up the road buzz plus being very stiff laterally.

Another option is nice rims such as Mavic Open Pro and Velocity with some trick hubs. You can play with nipple colors (no jokes here ) and spoke types so get a wheel tuned specifically for you. The price tag for such wheels could be less than factory-built wheels.

Your weight, ride types, typical road surface ridden, and frame material are all critical to making the choice.