Your sitbones will toughen up...
However, your girly bits up front are unlikely to... you can tilt the saddle down a little bit, but what that's going to cause is for you to slide forward, then you'll put more weight on your wrists and your wrists may hurt.
I don't know if it'll help a bit to slide your saddle forward on the rails since it sounds like you're sitting a bit forward on it? You do want your weight to rest on your sitbones, and not on your girlie bits.
A saddle with a cut out area in front is best for girlie bits - does your saddle have a cut out?
Blister on hand - are you holding too tight? where are you holding on the bike?
I guess if you post pictures of yourself riding the bike, some of us might try to comment on fit (which you should take with a grain of salt)



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