Some possible solutions to your hand pain:
1. If the nose of your saddle is tilted down to much it puts more weight on your hands.
2. You could try raising your handlebar height or rotating your bars so the hoods are higher to see if it's more comfortable.
3. Adjusting your position on the bike will help, but it will take some time for your contact points to get accustomed to riding. You shouldn't have to adjust your hand position every minute. If you have a genuine wrist issue you may try some of the elastic wrist bands that weight lifters use for added support.
PPP