For me it's mostly been chafing of the inner labia. As I said in the original post, trying that sample of chamois butt'r helped. I bought the bike from a shop where the owner is REALLY into proper bike fit, where he has equipment to set things up and makes adjustments involving a millimeter here, a millimeter there, etc. However, I wonder whether the angle of the seat might be an issue. Maybe it's slightly too high in the front or something. Thanks for all of the responses. This has been very helpful.