2 things to consider are saddle height and width.
I was having a terrible time on my terry butterfly, because it wasn't wide enough for my sit bones, so even with the cut-out, my soft tissues were supporting my body not my sit bones. Then, I had it a tad too high, so those tissues were getting sawed at with each pedal stroke. Not pretty.
For me, the solution was a Brookes Finesse Saddle, adsjuted so the nose is level, but that means the rear is quite a bit higher.
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Other stuff that has been mentioned like diet and hygeine is important too. For me, I got way less UTIs once I got my blood sugar under control. If you have sugar in your urine, that will encourage bacterial growth. I do swear by chamois butter, and even though I am pre-menopausal (or peri) estrogen levels do decline with age so I find it helps to use a vaginal estrogen cream once a week. Ask your doc to check your estrogen levels, and see if your soft tissues show signs of weakening estrogen.



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