Nope the bottles are angled out and back quite a bit, plus you can lower it on the seatpost if you want (it's harder to reach if you do that though.. mine is up as high as it can go without smashing my saddle bag). I can *almost* get bottles in and out just by feel now, but normally what happens is that I just swap one out in the front cage if I have to stop.

I don't think to date, that I've actually used more than a bottle and a half on any ride, but it's reassuring to know that I've got some extra fluids with me, just in case I need it