I ride a 19" (48cm) Terry Isis with 650cc wheels. Prior to that, I had a 49cm Fugi Roubaix with 700cc wheels and then a 44cm Specialized Dolce Comp also with 700 cc wheels.
Personally, I like the 650's. I like how they look on the smaller frame (the bike looks more in proportion) and I like how they ride. While I'm sure it has a lot to do with bike fit, frame material and general geometry, my Isis just rides better. It's way more responsive and quicker off the line than my other two bikes were. Because of my small profile, I'm also a bullet in descents (when I don't scare myself into breaking!)...even more so than my heavier husband.
I have no issues finding either tires or tubes (or wheels). I even got a flat during an MS150 a few years back and the SAG had a spare tube for me. 650's are popular enough these days that finding performance oriented gear is easy. It would probabaly be harder to find wider tires or touring type wheels in that size, but since mine is my 'go fast' road bike, it's not an issue for me.
My commuter has two different sized wheels. Now THAT is a pain. Two 650's? No biggie.![]()



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