When I first bought my tri bike, I had the same problem with pain in the "hot spot" area after a long ride - the saddle that came with the bike was a QR saddle with no cutout. I switched to a saddle with a cutout and it made all the difference - no more pain down there! I have the Terry Butterfly Tri saddle and really like it, although I wish the nose was just a little thinner. Too long on that one can produce saddle sores, though not every time. But for what you're experiencing, I'd first try a saddle with a cut-out, if you already don't have one. Good luck!