There is a Whole Foods in the next town, but I have never been there. It's in a direction I don't often travel. There is a TJ's about 3 miles from my house in Acton. I go there for certain things: the dark chocolate bars, huge flats of blueberries at certain times of year, some cheeses, etc. I find that the produce doesn't even come close to what's in the local chains and it looks limp and very small. So, I buy produce in the regular store, or starting in about a month at the local farm stands. The prices at TJ's are good. My son shops there for his regular shopping and he told me that it's about 30% cheaper for him.
I prefer to go the local natural foods store, which is homey, but has a huge selection, lots of prepared foods, and a bunch of people who actually know their customers (also free coffee and tea, reading material, tables, etc).