What MM_QFC said -- just have to be prepared that ride support or unfamiliar LBS's might not have what you need in a pinch. Luckily hasn't happened to me, but I think I will take the advice to port a spare tire on my next out of town ride.
Since R+E/Rodriguez has made a niche of building small bikes with 650c wheels, they ALWAYS have parts in stock for that wheel size. And they're a 10-minute ride from my house, so it's easy for me to drop in there and get what I need.