I put about 300 miles on an Aliante Gamma last year. I couldn't deal with the up-front pain. It wasn't really that I was supporting all my weight up front, I think it was just that since I ride in a fairly aggressive position (handlebars lower than the saddle) and move around a lot, it angled that sensitive area down into the seat a bit more, and after a long ride it just felt all chafed & irritated down there. From that little experiment I learned that I'm one of the girls who really, really need a cutout.

That said, in the rear, it was the most comfy saddle I've ever ridden - my butt did not hurt at all even after a really long ride. It's just that I'd rather have a sore bum than feeling like I'm peeing fire. If they ever come out with an Aliante with the same overall dimensions & shape but include a nice cutout, I'd probably be set.