I've been riding for 20+ years and if I am riding, I will eventually have saddle sores. I've tried many saddles/short combinations and for me, nothing has ever kept those little nasties from coming back. I have a theory that once you have had saddle sores, you are more prone to them and it is very difficult to keep them from forming.

Anyway, I do use some salves that have helped and keep them to a minimum, but for me, they are always a problem.