Search these forums on saddle fit.
Some soreness in the sitbones is to be expected as you ramp up saddle time. And of course when you're on the trainer you're in the same position for long periods of time, unlike on the road where you have a chance to move around and adjust your butt and shorts.
BUT, you shouldn't have to have chafing. A good fitting saddle and shorts are indispensable. Lots of people rely on lubes - and I'm one of them, I use paraben-free Beljum Budder - but lube shouldn't be your first line of defense against chafing. I'm not familiar with PowerGlide, but most runners' lubes really aren't meant to be used "down there." Some of them have some nasty ingredients. Plus IMO a lube needs to be a little gloppy to be effective on a woman's external genitalia.
If you're getting clogged pores or ingrown hairs, definitely try a different lube, and avoid shaving or waxing the saddle area if possible (but do keep the hair trimmed). If you're prone to pimples in the creases between your butt and your legs, I sometimes dry and disinfect that area with a little rubbing alcohol on a cotton ball or wad of TP after my shower.
If you think you have a cyst, search on that - several TE'rs have had nasty perineal cysts, some of them have had to be drained by a doctor.



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I had never thought about being in the same position for a longer time, without the steering...steering is so much more interesting 


JMO.

