I'd say go for it if you have a personal goal, but have a back-up plan. Any buses you can take if it gets too bad? Anyone to call? If not maybe carry a thermos with a hot drink. Eat well in advance. Put on some water-free skin cream on exposed skin, be ready to jump off your bike and run a little if your feet start getting too cold. Ice is less slippery at 10 F than at 20 F, and I'm guessing you have studded tires already. I'd be more concerned about snow in the air obscuring your (and drivers') vision, and anything that might slow you down, like a strong headwind or snow on the ground.

you know all this stuff