I tend to stand on switchbacks. They're typically a bit steeper than the rest of the road, and by standing, I don't have to shift or mash to get around it. One thing a coach taught me was not to increase my pace when I stand. I used to stand and kinda hammer, but if I just stand and keep my heart rate the same, when I sit back down, I don't have to slow down to recover. Use the stand to stretch, air out the bottom, and get over a slightly steeper section.
For 3 days, I get to part of a thousand other journeys.