Could it be the saddle?

[Aquila]

After being abroad for 5+ months, I got back on my bike with it's perfectly comfy and familiar saddle and got really sore after a very short ride.

Then I remembered my A&D ointment, and voila, no more soreness.

Which leads me to ask if you've been lubing the area sufficiently?

[cobalt]

Have you had your sit bones measured? My trek store has this gel thing that you sit on and it tells how wide you are. I needed a wider seat than the Bontrager that my bike came with. I bought a Planet Bike which isn't a top brand I don't think but it made a huge difference.