Rarely, but sometimes. I've never had much luck with Tylenol for anything. It has never worked on my headaches, anyway. If I do take anything, it's ibuprofen for the anti-inflammatory effects. I don't want to just kill pain, but remove the cause. I don't usually, unless I'm sure I'll be better off with it. Yesterday I did take some preemptively before my 120 miler. And in the middle of the night last night, when I realized I was pretty achy and it would help - especially my knees from a killer uphill. I was up at 2am cleaning up kitty puke anyway.