I don't like wine and rarely drink any alcohol anymore. My HDL is quite high. Exercise and fiber-rich foods (the kind in oatmeal and beans) also help your cholesterol. Sometimes your genetic makeup is against you and all the exercise, healthy diet and wine in the world will not help.

I would say if you don't like to drink, then don't start drinking wine just for the health effects.

Also bear in mind that alcohol makes you dehydrated. If you're only having one glass then just downing a glass or two of water should head off any problems, but if you drink a lot of any alcohol it will mess with your hydration levels.