I am a mounted patrol officer as well as competitive event rider (and, obviously, a cyclist). On some of our mounted details we are on twelve hour shifts. Especially in the heat, even with a seasoned butt like mine, saddle sores happen if precautions are not taken. The BEST things I have found are:
1. Preparation H. I'm serious. Use it on any existing saddle sores and any place where you might chafe.
2. This stuff called Anti-Monkey Butt. I sometimes use the two together.
You can get anti-monkey butt on Amazon.com or through a tack store.
3. Udder balm. Not as good as preparation H but less embarassing to buy.
At the last concert I worked I was on 12 hour in the saddle days (as opposed to mids) and my lips got so sunburned despite my chapstick with sunscreen that I resorted to putting preparation H on my lips. And it helped! I should write heloise.