I'm riding a hybrid specifically because I have some shoulder injury, so the straight handlebars help. I have some soreness in the palm of my hands. Wouldn't call it pain really, but I do go through a lot of gloves and then it's fine for a while. My job also puts a lot of stress on my hands. I don't think it's nerve damage, but I do have some tingling and numbness from roatator cuff impingement. It just feels really tender on the palm of my hand.