Part of this depends on the predominant muscle fiber makeup in your glutes/thighs. If you're more slow twitch, you'll find that higher cadences are easier. Fast twitch needs lower cadences.
The best way to tell is trial and error. On a flat road, if you can maintain a high cadence for many miles, you're probably slow twitch. If you're more comfortable at a lower cadence (70-80 mph) on the flats, you probably have more fast twitch.
The point of this is that what works for one TE'er may not work for her sister!




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